MOONSHOT research & development programMitochondrial preemptive medicine

・Tongu, Y., Kasahara, T. et al. Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD. Scientific Reports (2025)
 https://www.nature.com/articles/s41598-025-87501-x

・Matsunaga, T., Akaike, T. et al. Supersulphides provide airway protection in viral and chronic lung diseases. Nature Communications (2023)
 https://www.nature.com/articles/s41467-023-40182-4#additional-information

・Wu, X., Seida, M., Abe, T. & Higashitani, A. Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca2+ overload in Caenorhabditis elegans. npj Aging (2023)
 https://www.nature.com/articles/s41514-023-00116-2

・Terui, H., Yamasaki, K. et al. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Science Immunology (2022)
 https://www.science.org/doi/10.1126/sciimmunol.abm9811

・Wu, X., Nagasawa, S. et al. Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson’s Disease Model of Caenorhabditis elegans. Int. J. Mol. Sci. (2022)
 https://doi.org/10.3390/ijms23179572

・Mishima, E., Ito, J., Wu, Z. et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature (2022)
 https://doi.org/10.1038/s41586-022-05022-3