Members
Research Organization Members
Abe Takaaki Professor M.D. Ph.D.
Message from the Project Manager
Japan has one of the fastest aging populations in the world. As people age, they develop hearing loss, muscle atrophy, and frailty and require nursing care. Therefore, there is an urgent need to extend the healthy life span in Japan. Since mitochondrial dysfunction is thought to be one of the causes of these conditions, restoring mitochondrial function is promising to reduce the need for nursing care, improve the quality of life of the elderly, realize a healthy old age, and even reduce social security costs. Thus, this project aims to develop mitochondria-mediated preemptive medicine to “detect aging and frailty at an early stage and achieve a healthy and long-lived society through stress-free intervention and treatment.” To achieve this goal, we will conduct “mito-omics research” to detect mitochondrial therapeutic responding groups by comparing normal subjects and patients, develop non-invasive sensors, and develop mitochondrial therapeutics. With the outcomes of these studies, we aim to easily detect mitochondrial dysfunctions that occur in the body and offer the best diet, exercise, and medication for the individuals.
- Hiroaki Tomita Elucidation of the mechanism of the involvement of mitochondrial dysfunction in the pathogenesis of depression
- Takashi Kamei Development of multi-omic analysis on cancer patients in the hospital (esophageal cancer, pancreatic cancer, colorectal cancer)
- Shin Fukudo Development on mito-omics analyses of Irritable bowel syndrome (IBS) in the hospital: Genomic and metagenomic elucidation of brain-gut correlation
- Soichi Ogishima Organization of an integrated clinical database
- Masaharu Nakayama Personal Health Records
- Atsushi Hozawa The use of Integrated analysis in concert with machine learning-based artificial intelligence methods Investigation of generational inheritance of genotype and phenotype
- Yasushi Okazaki Mitochondrial DNA (mtDNA) analysis of a three-generation family tree
- Atsushi Takatori Development of mitochondrial DNA biopsy in blood
- Takaaki Akaike Analysis of the linkage between mitochondria and breath-respiratory for the establishment of breath medicine-omics
- Hozumi Motohashi Quantitative Evaluation of Stress Response in Mice
- Atsushi Higashitani Mechanisms of mitochondrial damage in aging and neuromuscular disease models and development of methods to improve their functions
- Erina Kuranaga Analysis using animal models of disease and search for drugs and nutritional components for the prevention of the disease
- Haruki Kitazawa Consolidate the enterobacteria endemic miniature intestinal tracts for the development of functional foods
- Nobuhiro Takahashi Crosstalk between anaerobic bacteria and gastrointestinal epithelial cell mitochondria: Identification of signal metabolites and elucidation of their functions
- Takafumi Toyohara Development of iPS cell-derived artificial intestine
- Hiroaki Onoe Construction of an in vitro artificial intestine reproducing the coexistence of intestinal bacteria
- Takahito Ono Development of sensors for evaluation of mitochondrial function
- Takakazu Nakabayashi Development of a label-free measurement system for mitochondria and measurement of mitochondria
- Ryoichi Nagatomi Realization of effective rehabilitation and care prevention by whole generation strengthening training without dropout
- Satoru Ebihara Establish rehabilitation without load
- (Masahiro Kohzuki) 〃
- Satoru Nagatoishi Structural determination of mitofilin
- Chikashi Ishioka Development of new diagnostics and therapeutic targets through the collection of clinical specimens with patient clinical information in Biobank
- Gen Tamiya Consolidation of mitochondrial genome data and machine learning analysis with artificial intelligence
- Tomoyoshi Soga Development of cancer prevention and treatment methods by improving mitochondrial function
- Shinji Fukuda Approaches to understanding the mitochondrial-enterobacterial linkage
- Takuji Yamada Approaches to understanding the mitochondrial-enterobacterial linkage
- Paul Anderson Stress sensor
- Vadim Gladyshev Epigenome, Gut Bacterial Clock
- Laurie Comstock Intestinal flora analysis
- Elizabeth Jonas Functional and Structural Analysis of the Large Conductance Channel of the Mitochondrion